Zhuanggui Chen, MD., PH.D
Title
Director of Pediatric Intensive Care Unit (PICU)
Research Interests
Dr. Chen’s team mainly focuses on studying airway allergic diseases, such as asthma and rhinitis. During the last 5 years, they have established the HDM-induced asthma mouse model and found an interesting epithelium-derived molecule TSLP, which plays a key role in the airway remodeling. This research is funded by the Chinese National Academic Grants (The National Natural Science Foundation of China).
Dr. Chen’s practice area is the diagnosis and management of pediatric ICU patients, including children with severe asthma, pediatric acute distress of respiratory syndrome (PARDS) , viral encephalitis, post-transplant GVHD, bronchopulmonary dysplasia and so on. He also introduced innovative treatment and therapeutic strategies for pediatric critical dieases which have been attracting worldwide attention, for example, using methylprednisolone pulse therapy to alleviate pulmonry hemohage deuto idiopathic pulmananry hemosiderosis.
Education and Experience
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Research scholar of allergic diseases, Yong Loo Lin School of Medicine, National University of Singapore. (2014)
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PhD of Respiratory, the Sun Yat-Sen University, Guangzhou, China (2010-2013).
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Master of Pediatrics, Sun Yat-Sen University, Guangzhou, China(2000-2002).
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Bachelor of Medicine, School of Medicine, Sun Yat-Sen University, Guangzhou, China (1995-2000).
Publications
1. Hong-tao Li, Tian-tuo Zhang, Zhuang-gui Chen, Jin Ye, Hui Liu , Xiao-ling Zou, Yan-hong Wang, Hai-ling Yang. Intranasal administration of CpG oligodeoxynucleotides reduces lower airway inflammation in a murine model of combined allergic rhinitis and asthma syndrome. International Immunopharmacology 2015, 28:390–398.
2. Ping-Ping Zhang, Ya-Ting Li, Xiao-Feng Li, Li Pan, Zhuang-Gui Chen*. Clinical research on serum lipid changes in children with Kawasaki disease and its relationship with coronary artery lesions. Clin Exp Rheumatol. 2015, 33(2 Suppl 89):S-181.( *corresponsive author )
3. Zhuanggui Chen, Tiantuo Zhang, Hongtao Li, Chen Fenhua, Xiaoling Zou, Jingzhi Ji, Hong Chen . Neutralization of TSLP inhibits airway remodeling in a murine model of allergic asthma induced by chronic exposure to house dust mite. 2013, PLoS One. 8(1): e51268.
4. Chen Zhuang-Gui, Li Ming，Chen Yan-Fen, Ji Jing-Zhi*, Li Ya-Ting, Chen Wei, Chen Fen-Hua, Chen Hong. Effects of dermatophagoides pteronyssinus allergen specific immunotherapy on the serum IL-13 level and pulmonary functions of asthmatic children. Chin Med J. 2009, 122(10):1157-1161.
5. Zhuanggui Chen, Lifen Yang，Yating Li, et al. Neonatal cutaneous aspergillosis accompanied by hemophagocytic lymphohistocytosis. Pediatr Infect Dis J. 2017.36(4):423-425.
6. Ya-Ting Li, Yu-Xiong Guo ,Liang-Ming, Li Pan, Meng-Qi Duan, Li-Fen Yang, Yue-Yu Sun, Wei-Ping Tan, Zhuang-Gui Chen. Methylprednisolone pulse therapy rescued life-threatening pulmonary hemorrhage due to idiopathic pulmonary hemosiderosis. Am J Emerg Med. 2017, (17):30643-5. doi: 10.1016/j.ajem.2017.07.094
7. Ming Li Zhao, Ni Wang, Li‑Fen Yang, Yan Yan, Liang‑Ming Cai, Ya‑Ting Li, Yong‑Kang Qiao, Zhuang‑Gui Chen. TLR4 antagonist suppresses airway remodeling in asthma by inhibiting Th2 response. Experimental and Therapeutic Medicine. 2017,14:2911-2916.
8. Xiaofeng Li, Huiqin Chen, Yun Cai, Zhuanggui Chen. Association of STAT4 and PTPN22 polymorphisms and their interactions with type-1 autoimmune hepatitis susceptibility in chinese han children. Oncotarget. 2017 Apr 27. doi: 10.18632/ oncotarget.17458.
9. Shao-Hong Huang, Qing-Lei Kong, Xue-Xia Chen, Jin-Yuan He, Jie Qin, Zhuang-Gui Chen. Adrenalectomy does not improve survival rates of patients with solitary adrenal metastasis from non-small cell lung cancer. Ther Clin Risk Manag. 2017,13:355-360.
10. Yu-Xiong Guo, Zhao-Ni Wang, Ya-Ting Li, Li Pan, Li-Fen Yang, Yan Hu, Yue-Yu Sun, Liang-Ming Cai, Zhuang-Gui Chen. High-Frequency Oscillatory Ventilation is an effective treatment in Severe Pediatric Acute Respiratory Distress Syndrome with Refractory Hypoxemia. Ther Clin Risk Manag. 2016, 12:1563-1571.
11. Zhuang-gui Chen, Hong-tao Li, Hui Liu , Jin Ye , Xiao-ling Zou , Yan-hong Wang , Hai-ling Yang , Ping Meng , Tian-tuo Zhang . Treatment of allergic rhinitis with CpG oligodeoxynucleotides alleviates the lower airway outcomes of combined allergic rhinitis and asthma syndrome via a mechanism that possibly involves in TSLP. Exp Lung Res. 2016;42(6):322-33.
Contact
Dept. of Pediatrics Intensive Care Unit (PICU),
The 3rd Affiliated Hospital, Sun Yat-Sen University
600 Tian He Road, Guangzhou, Guangdong, P.R. China 510630
Appointment Phone: 86-20-85252093
E-mail:Chenzhuanggui@126.com
