Ka Zhang, Ph.D.

Titles

Associate Professor of infectious diseases

Master's Supervisor

Department of Infectious Diseases, The Third Affiliated Hospital of SunYat-Sen University

Research Interests

Clinical diagnosis and treatment of infectious diseases, especially hepatitis

The pathogenesis of HBV or HCV infection

Clinical diagnosis and treatment of cirrhosis and cancer of the liver

Education and Experience

2000-2005  Clinical Medicine, the medical school of Zhengzhou University , Zhou Zheng , NanHe Province

2005-2007  Master of Medicine, Sun Yat-sen University, The Third Affiliated Hospital, Guangzhou , Guangdong province

2007-2010  M.D, Ph.D (medicine ), Sun Yat-sen University, The Third Affiliated Hospital, Guangzhou , Guangdong province

2010-2015 Lecturer of Medicine, Sun Yat-sen University, Zhongshan School of Medicine, Guangzhou Guangdong province

2016-To now Associate Professor of Hepatology, Sun Yat-sen University, Zhongshan School of Medicine, Guangzhou, Guangdong province

2010-2011 Resident, Department of Infectious Diseases(Liver Center), the Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong province

2012-2016 Attending Physician, Department of Infectious Diseases(Liver Center), the Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong province

2017  to now  Associate Chief Physician, Department of Infectious Diseases(Liver Center), the Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong province

Honors and Awards

My research focuses on treatment of acute-on-chronic liver failure with hepatitis B and exploration of the mechanism of acute-on-chronic HBV liver failure, and the mechanism of liver cirrhosis and liver cancer

1.The National Natural Science Foundation of China, 2016-2018, head of the program.

2.The Medical Scientific Research Foundation of Guangdong Province, 2012-2014, head of the program.

3.The Medical Research Fund of Guangdong Pharmaceutical Association (Grant Nos. 2012GRS01 and 2013GRS06).

Publications

The main original articles that were published in the past five years as the following: 

1: Zhang K, Cao H, Liang J, Shu X, Sun H, Li G, Xu Q. CONSORT: Effects of adding adefovir dipivoxil to peginterferon alfa-2a at different time points on HBeAg-positive patients: A prospective, randomized study. Medicine (Baltimore). 2016 Aug;95(31):e4471. doi: 10.1097/MD.0000000000004471. PubMed PMID: 27495085;PubMed Central PMCID: PMC4979839.

2: Zhang K, Shu X, Luo HF, Zhu FQ, Cao H, Xu QH, Li G. [ROG,GATA3 and T-bet mRNA  levels in peripheral blood mononuclear cells in patients with chronic hepatitisB]. Nan Fang Yi Ke Da Xue Xue Bao. 2016 Feb;36(2):186-9. Chinese. PubMed PMID:26922013.

3: Xiao CH, Sun HX, Zhang K, Pan XF, Huang FF, Xu QH. [Comparative study on the clinical characteristics of HBV infection patients with different pathologic inflammation grade]. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2013 Aug;27(4):270-2. Chinese. PubMed PMID: 24579472.

4: Lai J, Sun HX, Jie YS, Zhang K, Ke WM. Serum HBsAg level and its clinical significance in lamivudine treatment for patients with HBeAg-negative acute-on-chronic liver failure. Int J Infect Dis. 2014 May;22:78-82. doi:10.1016/j.ijid.2013.12.018. Epub 2014 Feb 8. PubMed PMID: 24518440.

5: Cao H, Pan XF, Zhang K, Shu X, Li G. [Interleukin-32 expression is induced by  hepatitis B virus]. Zhonghua Gan Zang Bing Za Zhi. 2013 Jun;21(6):442-5. doi:10.3760/cma.j.issn.1007-3418.2013.06.014. Chinese. PubMed PMID: 24034846.

6: Pan X, Zhang K, Yang X, Liang J, Sun H, Li X, Zou Y, Xu Q, An G, Li G, Xu Q. Relapse rate and associated-factor of recurrence after stopping NUCs therapy with different prolonged consolidation therapy in HBeAg positive CHB patients. PLoS One. 2013 Jul 3;8(7):e68568. doi: 10.1371/journal.pone.0068568. Print 2013. PubMed PMID: 23844222; PubMed Central PMCID: PMC3701059.

7: Zhang K, Pan X, Shu X, Cao H, Chen L, Zou Y, Deng H, Li G, Xu Q. Relationship  between MIF-173 G/C polymorphism and susceptibility to chronic hepatitis B andHBV-induced liver cirrhosis. Cell Immunol. 2013 Apr;282(2):113-6. doi:10.1016/j.cellimm.2013.04.013. Epub 2013 May 6. PubMed PMID: 23770720.

8: Pan XF, Zhang K, Yang XA, Li XJ, Xu QH. [Interleukin-21 expression in serum of patients with acute-on-chronic liver failure and its significance]. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2012 Dec;26(6):477-9. Chinese. PubMed PMID:23627035.

9: Lai J, Gan WQ, Xie DY, Zhang K, Ke WM, Gao ZL. [Dynamics of serum HBV DNA levels during the terminal phases of acute-on-chronic hepatitis B liver failure with different HBeAg status]. Zhonghua Gan Zang Bing Za Zhi. 2012Jul;20(7):522-5. doi: 10.3760/cma.j.issn.1007-3418.2012.07.009. Chinese. PubMed PMID: 23044238.

10: Xu Q, Pan X, Shu X, Cao H, Li X, Zhang K, Lu J, Zou Y, Li X, Liu H, Zhang Y, Yang D, Ning Q, Shen G, Li G. Increased interleukin-32 expression in chronic hepatitis B virus-infected liver. J Infect. 2012 Oct;65(4):336-42. doi:10.1016/j.jinf.2012.05.009. Epub 2012 Jun 8. PubMed PMID: 22687868.

11: Cao H, Zhang K, Shu X, Xu QH, Li G. [Detection of core antigen of hepatitis virus C in patients infected with hepatitis virus C and B]. Zhonghua Gan Zang Bing Za Zhi. 2011 Oct;19(10):726-8. doi: 10.3760/cma.j.issn.1007-3418.2011.10.002. Chinese. PubMed PMID: 22409841.

12: Liang JY, Yang XA, Zhang K, Chen LB, Shu X, Xu QH. [A clinical study on the efficacy of HBeAg-positive chronic hepatitis B patients treated with adefovir dipivoxil for 4 years]. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2011Oct;25(5):384-6. Chinese. PubMed PMID: 22338232.

13: Cao H, Zhang K, Shu X, Xu QH, Li G. [Detection of hepatitis C core antigen in intravenous drug addictions]. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2011 Aug;25(4):304-6. Chinese. PubMed PMID: 22097615.

14: Zhang K, Cao H, Yang XA, Hong XL, Chen LB, Shu X, Li G, Xu QH. [Comparative study on the clinical characteristics of HBV/HCV co-infection patients with different HCV contaminnation mode]. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2011 Aug;25(4):301-3. Chinese. PubMed PMID: 22097614.

15: Sun HX, Cao H, Zhang K, Yang XA, Li G, Xu QH. [The levels of HBsAg can predict the efficacy of peglated interferon-alpha 2a combined with adefovir dipivoxil, in HBeAg-positive chronic hepatitis B patients]. Zhonghua Shi Yan HeLin Chuang Bing Du Xue Za Zhi. 2011 Apr;25(2):132-4. Chinese. PubMed PMID: 21863639.

16: Yang XA, Zhang K, Shu X, Cao H, Xu QH. [Adenoviruses mediated BCL-X1 overexpression protects mice from fulminant hepatic failure]. Zhonghua Shi Yan HeLin Chuang Bing Du Xue Za Zhi. 2011 Apr;25(2):109-11. Chinese. PubMed PMID:21863631.

17: Hong XL, Cao H, Zhao F, Pan XF, Zhang K, Xu QH, Zhao ZX, Li G. [MiR-196a-2gene polymorphism and the antiviral therapy of chronic hepatitis C]. Zhonghua ShiYan He Lin Chuang Bing Du Xue Za Zhi. 2010 Dec;24(6):470-2. Chinese. PubMed PMID:21604580.

18: Chen LB, Cao H, Zhang YF, Shu X, Chen N, Zhang K, Li G, Xu QH. [Efficacy ofantiviral treatment on patients with acute-on-chronic hepatitis B liver failurewith low viral load]. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2010Oct;24(5):364-6. Chinese. PubMed PMID: 21280326.

19: Cao H, Shu X, Chen LB, Zhang K, Xu QH, Li G. [The relationship of expression of BMP-7 in the liver and hepatic inflammation and fibrosis in patients withchronic HBV infection]. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2010Apr;24(2):101-3. Chinese. PubMed PMID: 21110425.

20: Jie YS, Chen LB, Shu X, Yang XA, Zhang K, Xu QH, Li G. [The effect ofantiviral therapy for patients with HBeAg-negative cirrhosis]. Zhonghua Shi YanHe Lin Chuang Bing Du Xue Za Zhi. 2010 Feb;24(1):45-7. Chinese. PubMed PMID:20848849.

21: Chen LB, Shu X, Jie YS, Yang XA, Zhang K, Li G, Xu QH. [Short-term efficacyof adefovir dipivoxil as an add-on therapy in the pegylated IFNalpha-2a treatmentfor HBeAg positive chronic hepatitis B patients]. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2010 Feb;24(1):39-41. Chinese. PubMed PMID: 20848847.

22: Xu QH, Chen LB, Xu Z, Shu X, Chen N, Cao H, Zhang K, Li G. [The short-termefficacy of antiviral treatment in patients with acute-on-chronic hepatitis Bliver failure]. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2009Dec;23(6):467-9. Chinese. PubMed PMID: 20718359.

23: Wei ZW, Xu QH, Shu X, Jie YS, Zhang K, Xie QF, Li G. [The antiviral treatmentimpacts on clinical outcomes of renal transplantation recipients with hepatitis Bvirus infection]. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2009Jun;23(3):224-6. Chinese. PubMed PMID: 20104785.

24: Xu QH, Shu X, Chen LB, Zhang K, Li G. [Comparison of clinical features frompatients with chronic hepatitis B between HBeAg negative and positive]. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2009 Jun;23(3):211-3. Chinese. PubMedPMID: 20104781.

25: Zhang K, Xu QH, Chen LB, Shu X, Chen N, Li G. [Correlation of serum chemokineRANTES level with serum biochemical indices, HBeAg and HBV DNA load in patientswith chronic hepatitis B]. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi.2009 Jun;23(3):188-90. Chinese. PubMed PMID: 20104774.

26: Chen LB, Huang HH, Shu X, Xu QH, Chen N, Zhang K, Li G. [Pathological studyof liver biopsy from 156 patients clinically diagnosed with mild chronichepatitis B based on current guideline]. Zhonghua Shi Yan He Lin Chuang Bing DuXue Za Zhi. 2009 Apr;23(2):138-40. Chinese. PubMed PMID: 20104760.

27: Shu X, Xu QH, Chen N, Zhang K, Li G. [The clinic features and the short-term efficacy of entecavir treatment of the HBeAG negative acute-on-chronic hepatitis B liver failure]. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2008Dec;22(6):481-3. Chinese. PubMed PMID: 19544652.

28: Xu QH, Shu X, Chen LB, Huang HH, Zhang K, Li G. [Relationships between liver function test, serum HBeAg or HBV DNA level and liver pathological changes inpatients with chronic hepatitis B]. Zhonghua Shi Yan He Lin Chuang Bing Du Xue ZaZhi. 2008 Dec;22(6):422-4. Chinese. PubMed PMID: 19544633.

29: Zhang K, Xu QH, Chen LB, Shu X, Cao H, Li G. [The measurement andsignificance of serum chemokine RANTES in patients with chronic hepatitis B].Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2008 Aug;22(4):293-5. Chinese.PubMed PMID: 19105348.

Contact

Department of Infectious Disease

The Third Affiliated Hospital of the Sun Yat-sen University

No 600# Tianhe Road, Guangzhou, 510630, P. R. China

Appointment Phone: +86 020-85252372