Bo Hu, PhD
Titles
Professor of Laboratory Medicine
Director，Department of Laboratory Medicine, Third Affiliated Hospital of Sun Yat-sen University
Member of American Association for Cancer Research
Research interests
Molecular mechanism of intestinal metaplasia in the Barrett's Esophagus;
Disease gene diagnosis, Development of tumor diagnostic reagents and The application of Recombinant protein technology in clinical immunological detection.
Education and Experience
Training
PhD , Sun Yat-sen University, School of Medicine(2007)
MS ,Wuhan University，School of Medicine (1999)
Honors and Awards
The third prize of scientific and technical progress of Guangdong province(2011)
Publications
（1） ZhaoFan Luo*, Bo Hu*, FengYi Zhang, XiangHua Lin, XiaoYing Xie, KunYi Pan，HongYu Li, RuiWen Ren, and WenZhong Zhao. Laboratory and molecular characterization of dengue virus during the 2014 outbreak in Guangfo region, Southern China. Japanese Journal of Infectious Diseases. 2017 Mar 28..
（2） Kebing Wang, Chengming Yang, Jiajun Ye, Fanqi Zeng, Yanling Duan, Yi Zheng, Bo Hu*, Xilan Yu*. Inhibition of herpesviruses (HSV) replication by á-TIF siRNA-loaded PLGA-TPGS nanoparticles in vitro and in vivo. Journal of Biomedical Nanotechnology （3） Zheng Y, Hu B, Xie S, Chen X, Hu Y, Chen W, Li S,Hu B*. Dendritic cells infected by Ad-sh-SOCS1 enhance cytokine-induced killer (CIK) cell immunotherapeuticefficacy in cervical cancer models. Cytotherapy. 2017;19(5): 617- 628.
（4） Hubo, Shanshan Li， Zhanfeng Zhang，Shenggao Xie，Yuqian Hu， Xianzhang Huang，Yi Zheng. HCV NS4B targets Scribble for proteasome-mediated degradation to facilitate cell transformation. Tumour Biol. 2016 ;37(9):12387-12396.
（5） Xueping Qiu*, Bo Hu*, Yifang Huang, Yunte Deng, Xuebin Wang, Fang Zheng. Hypermethylation of ACP1, BMP4, and TSPYL5 in Hepatocellular Carcinoma and Their Potential Clinical Significance. Digestive Diseases and Sciences. 2016 Jan;61(1):149-57.
（6） Xinliang Sun, Hongbo Chen, Zaian Deng, Bo Hu, Hui Luo,Xiaobin Zeng, Liqiao Han, Guoping Cai1 and Lan Ma. The Warsaw breakage syndrome-related protein DDX11 is required for ribosomal RNA synthesis and embryonic development. Human Molecular Genetics. 2015 Sep 1;24(17):4901-4915.（IF 6.393） （7） Chen H, Liang ZW, Wang ZH, Zhang JP, Hu B, Xing XB, Cai WB. Akt Activation and Inhibition of Cytochrome C Release: Mechanistic Insights into Leptin-promoted Survival of Type II Alveolar Epithelial Cells. Journal of Cellular biochemistry. J Cell Biochem. 2015 Oct;116(10):2313-24. （8） Hu B, Chen H, Liu X, Zhang C, Cole GJ, Lee JA, Chen X. Transgenic overexpression of cdx1b induces metaplastic changes of gene expression in zebrafish esophageal squamous epithelium. Zebrafish. 2013 ;10(2):218-227
（9） Bo Hu, Chengjing Zhang, Kouwendy Baawo, Rong Qin, Gregory J. Cole, Ju-Ahng Lee, Xiaoxin Chen. Zebrafish K5 Gene Driven GFP Expression as a Transgenic Model of the Oro-esophageal System. Oral oncology 2010;46:31-37
（10）Pei Wang and Bo Hu. Strategies on reducing blood culture contamination. Reviews in Medical Microbiology. 2012;23:63-66
（11）Zhaoxia Li, Guoqiang Hong, Zhonghua Wu, Bo Hu, Jue Xu, Lin Li. Optimization of the expression of hepatitis B virus e gene in Pichia pastoris and immunological characterization of the product. Journal of Biotechnology 2008;138(1-2):1-8
（12）Hu, B., Hong, GQ., Li, ZX., Xu, J., Zhu, ZY., Li, L. Expression of VCA and EBNA1 genes of Epstein-Barr virus in Pichia pastoris and application of the products in a screening test for patients with Nasopharyngeal carcinoma. Biotechnology and applied biochemistry 2007(Pt1);47,59-69
（13）Li, ZX., Hong, GQ., Hu, B., Liang, MJ., Xu, J., Li, L. Suitability of yeast- and Escherichia coli-expressed hepatitis B virus core antigen derivatives for detection of anti-HBc antibodies in human sera. Protein Expr Purif. 2007 ;56(2):293-300
（14）Hu, B., Liang, MJ., Hong, GQ., L, ZX., Zhu, ZY., Li, L.Expression of hepatitis B virus S gene in Pichia pastorios and application of the product for
detection of anti-HBs antibody, Journal of Biochemistry and Molecular Biology,2005,38(6):683-689.
Contact
Department of Laboratory Medicine,
Third Affiliated Hospital, Sun Yat-sen University,
600 , Tianhe Road,Tianhe District
Guangzhou, P.R.China 510630
Tel: 86-20-85253057(office)
