Mengyin Cai, M.D., Ph.D
Titles
Associate Professor of Endocrinology
3rd Affiliated Hospital of Sun Yat-sen University
Research Interests
Genetics and epigenetics of diabetes.
Education and Experience
Associated Professor, 2010.12-
Attending Doctor, 2003.06-2010.11
Resident Physician, 1998.07-2003.05
Postdoctoral positions: 2011.02-2012.12, Lund University Diabetes Centre
Doctoral degree: 2007, Ph.D, Sun Yat-sen University
Higher education degree: 1998, M.D., Sun Yat-sen University
Honors and Awards
Member of Junior Board of Chinese Diabetes Society
Member of Board of Guangdong Province Diabetes Society
Publications
1. Zheng X, Xu F, Liang H, Cao H, Cai M, Xu W, Weng J. SIRT1/HSF1/HSPs Pathway is Essential for Exenatide-alleviated Lipid-induced Hepatic Endoplasmic Reticulum Stress. Hepatology. 2017 Sep;66(3):809-824.
2. Xu F, Zheng X, Lin B, Liang H, Cai M, Cao H, Ye J, Weng J. Diet-induced obesity and insulin resistance are associated with brown fat degeneration in SIRT1-deficient mice. Obesity (Silver Spring). 2016 Mar;24(3):634-42.
3. De Marinis Y, Cai M, Bompada P, Atac D, Kotova O, Johansson ME, Garcia-Vaz E, Gomez MF, Laakso M, Groop L. Epigenetic regulation of the thioredoxin-interacting protein (TXNIP) gene by hyperglycemia in kidney. Kidney Int. 2016 Feb;89(2):342-53. (Co-first author)
4. Cai M, Bompada P, Atac D, Laakso M, Groop L, De Marinis Y. Epigenetic regulation of glucose-stimulated osteopontin (OPN) expression in diabetic kidney. Biochem Biophys Res Commun. 2016 Jan 1;469(1):108-13.
5. Zhang Y, Xu F, Liang H, Cai M, Wen X, Li X, Weng J. Exenatide inhibits the growth of endometrial cancer Ishikawa xenografts in nude mice. Oncol Rep. 2016 Mar;35(3):1340-8.
6. Liang H, Xu J, Xu F, Liu H, Yuan D, Yuan S, Cai M, Yan J, Weng J. The SRE Motif in the Human PNPLA3 Promoter (-97 to -88bp) Mediates Transactivational Effects of SREBP-1c. J Cell Physiol. 2015 Sep;230(9):2224-32.
7. Yao B, Zhang X, Liang H, Xu W, Cai M, Yan J, Weng J. 6q24 transient neonatal diabetes mellitus: the first case report fromChina. Chin Med J (Engl). 2014;127(20):3680.
8. Tuomi T, Santoro N, Caprio S, Cai M, Weng J, Groop L. The many faces of diabetes: a disease with increasing heterogeneity. Lancet. 2014 Mar 22;383(9922):1084-94.
9. Bi Y, Wu W, Shi J, Liang H, Yin W, Chen Y, Tang S, Cao S, Cai M, Shen S, Gao Q, Weng J, Zhu D. Role for sterol regulatory element binding protein-1c activation in mediating skeletal muscle insulin resistance via repression of rat insulin receptor substrate-1 transcription. Diabetologia. 2014 Mar;57(3):592-602.
10. Bi Y, Tong GY, Yang HJ, Cai MY, Ma JH, Liang J, Xin B, Miao H, Peng ZH, Zhu DL. The beneficial effect of metformin on β-cell function in non-obese Chinese subjects with newly diagnosed type 2 diabetes. Diabetes Metab Res Rev. 2013 Nov;29(8):664-72.
11. Ye C, Li X, Wang Y, Zhang Y, Cai M, Zhu B, Mu P, Xia X, Zhao Y, Weng J, Gao X, Wen X. Diabetes causes multiple genetic alterations and downregulates expression of DNA repair genes in the prostate. Lab Invest. 2011 Sep;91(9):1363-74.
12. Shen Y, Cai M, Liang H, Wang H, Weng J. Insight into the biochemical characteristics of a novel glucokinase gene mutation. Hum Genet. 2011 Mar ;129(3):231-8. (Co-first author)
13. Sun W, Bi Y, Liang H, Cai M, Chen X, Zhu Y, Li M, Xu F, Yu Q, He X, Ye J, Weng J. Inhibition of obesity-induced hepatic ER stress by early insulin therapy in obese diabetic rats. Endocrine. 2011 Jun;39(3):235-41.
14. CAI Meng-yin, LIANG Hua, LI Ming, BI Yan, CHEN Xiang, SUN Wei-ping, WENG Jian-ping. Lamin C protein deficiency in the primary fibroblasts from a new laminopathy case with ovarian cystadenoma. Chinese Medical Journal 2010; 123(16):2237-2243.
Fundings
National Natural Science Foundation of China
Natural Science Foundation of Guangdong Province,China
Science and Technology Planning Project of Guangdong Province, China
Promoting Project for Junior Teachers of Sun Yat-sen University
Contact
3rd Affiliated Hospital of Sun Yat–sen University
600# Tianhe Road, Tianhe District, Guangzhou
510630
Telephone: +862085253193
